Download fulltext pdf download fulltext pdf trastuzumab. Herceptin trastuzumab is a human monoclonal antibody that interferes with the her2 receptor. Updated mechanisms of action and resistance in breast cancer article pdf available in frontiers in oncology 2. Trastuzumab, sold under the brand name herceptin among others, is a monoclonal antibody used to treat breast cancer.
Trastuzumab is approved by the food and drug administration for patients with invasive breast cancers that overexpress her2. Trastuzumab has been proposed to trigger her2 internalization and degradation through promoting the activity of tyrosine kinase ubiquitin ligase ccbl klapper et al. Get emergency medical help if you have signs of an allergic reaction. Md anderson cancer center investigators conducted a study that compared paclitaxel followed by 5fluorouracil, epirubicin, and cyclophosphamide fec with or without trastuzumab. The first dose is given over 90 minutes, and the following doses are usually given over 30 minutes. W agner ad, u nverzagt s, grothe w, kleber g, grothey a, haerting j. Cari tahu informasi medis lengkap dan terverifikasi tentang fungsi trastuzumab, efek samping, keamanan, interaksi, dan peringatannya di hello sehat.
Trastuzumab, a recombinant antibody targeting her2, was the first biological drug approved for the treatment of her2positive bc. Trastuzumab herceptin american journal of neuroradiology. Trastuzumab was evaluated in several small studies in the neoadjuvant setting. Although there are currently other antiher2 agents available e. Trastuzumab is given by slow injection into a vein and injection just under the skin. Given intravenously on day 1, every 21 days until disease progression or unacceptable toxicity.
In particular, trastuzumab does not seem to be able to prevent ligandactivated her2her3 or her2her1 heterodimerization which could give tumor cells a way to escape from the inhibitory effects of trastuzumab ghosh et al. Us food and drug administration her, her2, her3, and her4. Drug therapy trastuzumab mechanism of action and use. Pertuzumab trastuzumab name of proposed course of treatment include brief explanation if medical term not clear pertuzumab and trastuzumab for the treatment of breast cancer. It was observed that the binding of trastuzumab to her2 recruits ccbl to its docking site, tyr 1112 where ccbl ubiquitinates her2 and leads to its degradation. Trastuzumab mechanism of action and use in clinical. Tell your caregiver right away if you feel dizzy, nauseated, itchy, lightheaded, weak, short of breath, or if you have a headache, fever, chills. Department of radiation oncology, nanfang hospital, southern medical. A large well designed multicentre study found that the addition of trastuzumab to. Trastuzumab is an integral part of adjuvant therapy in women with highrisk primary breast tumors that overexpress or amplify her2. Binding with high affinity to the extracellular domain of her2, trastuzumab inhibits the proliferation of tumour cells that overexpress her2.
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